Dr. Avula Balakrishna

HOD &Assistant Professor

Department of Chemistry

Rajeev Gandhi Memorial College of Engineering & Technology (Autonomous)

NAAC A+ grade

Nandyal-518 501, A.P. India

Mobile: +91-9849491775





Ph.D. 2010. Chemistry, with emphasis in Organic Chemistry

Thesis:Synthesis, spectral characterization, and bioactivity studies on some novel organophosphorus compounds(Prof. Dr. C. Suresh Reddy, thesis advisor)


Sri Venkateswara University,

Tirupati, India

M.Phil.  2007. Chemistry


Sri Venkateswara University,

Tirupati, India

M.Sc. 2005.Organic Chemistry


Sri Venkateswara University,

Tirupati, India

B.Sc.     2003. Chemistry, Bio-Chemistry & MB                              Sri Venkateswara University,

Tirupati, India

Research Experience

Postdoctoral Research Associate, University of Delaware, USA                 Feb, 2015- Feb, 2016

Advisor: Dr. Deb P. Jaisi

  • Synthesis of isotope labeled organophosphorus compoundsincluding characterizationof reactions, intermediates and end products by using an array of advanced analytical tools including IR, 1H NMR, 31P NMR,ESI-mass spectroscopies and Thermo Chemolysis/Elemental Analyzer (TC/EA).
  • Functional group Inter-conversionin glyphosate to enhance isotope discrimination.
  • Application of oxygen isotopes in phosphate as a tracer fordetection and source identification of glyphosate and its degradation products.

Postdoctoral Fellow, University of Coimbra, Portugal, EU 2011-2014

Advisor: Prof. Abilio N. Sobral

  • Synthesis of New Metal Organic Frameworksbased on Porphyrins for bio-medicinal applications and also CO2and CH4sequestering andin-situchemical conversion.

Senior Research Fellow, Sri Venkateswara University,Tirupati 2006-2010


Advisors: Prof. C. Suresh Reddyand Prof. C. Devendranath Reddy

  • Synthesis of novel organophosphorus compounds ofbiological and commercial importance


Research Fellowships and Awards

2011-2014FCT Post-Doctoral Fellowship (funded by Portuguese Government)
2007-2010 Senior Research Fellow (BARC, DAE, Mumbai), Government of India,
2006-2007University Merit Fellowship, Sri VenkateswaraUniversity, Tirupati, India

Field of Interest

• Synthetic Organic and Medicinal Chemistry
• Development of New Organic Transformations Mediated by OrganometallicCompounds
• Synthesis Using TransitionMetal Complexes as Catalysts
Research Skills

• Developed simple synthetic protocol for ?-aminophosphonates and evaluated their anti-cancer activity.
• Accomplished synthesis of novel bis-phosphonates and evaluated their anti-bone resorption properties.
• Designed and synthesized potent anti-oxidant/anti-microbial agents such as novel thiadiaza phosphol-2-ones and 1, 2-benzoxaphosphol-2-ones.
• Organic synthesis, in particular those aspects related to heterocyclic compounds such as- Synthesis of pyrroles, porphyrins and metalloporphyrins used in medicinal Chemistry, biomedicine, and environmental technologies.
• Synthesis of Organometallic complexes and MOFs for CO2 capture technologies.
• Synthesis of Phosphate-Oxygen Isotope labeled compounds for agriculture applications and in geochemistry.
• Reporting of results to departmental leads through both written and verbal communication. Reporting and protection of results externally through appropriate publications and presentations.
• Expertise in chromatographic purification, spectral characterization, process research and Scale-up operations

Technical Experience

• Experience in handling air- moisture-sensitiveand explosive compounds, Organic, Organo- metallic preparative chemistry

• Interpreting data for Fourier Transform-Infrared Spectroscopy (FT-IR), Mass analytical tool (GC-MS, ESI and FAB), HPLC,Multi Nuclear Magnetic resonance (NMR) spectroscopy, UV/visible spectroscopy.

Teaching Experience

• 2007-2010 Organic chemistry (teaching assistant in laboratory classes) for Master degree courses, Sri Venkateswara University, Tirupati, India.
• 2011-2014 Mentoring Masters’ degree students in research and presentations, University of Coimbra, Portugal.
Professional Service

• Frequent reviewer of manuscriptsin: Environmental Science & Technology, Synthetic Communications, Heterocyclic Communications, Phosphorus Sulfur Silicon and Its Related Elements, and Journal of Chemistry

Personal Details

Nationality: Indian
Date of Birth: 19-06-1979
Passport number & Date of Expiry: Z3981637 (19-12-2026)
Peer Reviewed Publications : 26

1. Solar and visible active amino porphyrin/SiO2-ZnO for the degradation of naphthol blue black.
Krishnakumar Balu,Avula Balakrishna, V Pandiyan, António Aguiara, Abilio Sobral,Journal of Physics and Chemistry of Solids 111,364-371,2017.
2. Removal of hydrogen sulfide generated during anaerobic treatment of sulfate-laden wastewater using biochar: Evaluation of efficiency and mechanisms.
J. Kanjanarong, B. S. Giri, D. P. Jaisi, F. Oliveira, P. Boonsawang, S.Chaiprapat, R. S. Singh, Avula Balakrishna, Samir Kumar Khanal, 234, 115-121, Bioresource Technology2017. Impact factor: 4.915
3. Chemically modified amino porphyrin/TiO2 for the degradation of Acid Black 1 under day light illumination.
B.Krishna Kumar,Avula Balakrishna, Cláudia T. Arranja, Carlos M. F. Dias, Abilio J. F. N. Sobral,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017, 176, 134-141. Impact factor: 2.15
4. Mechanisms of bond cleavage during Mn oxide and UV degradation of glyphosate: Results from phosphate oxygen isotopes and molecular simulations.
Jaisi DP, Li H, Wallace AF, Paudel P, Sun M, Balakrishna A, Lerch BN,
Journal of Agricultural and Food Chemistry,2016, 64 (45), pp 8474–8482. IF: 4.515
5. Porphyrins as nanoreactors in the carbon dioxide capture and conversion: a review .
Santosh Kumar, Mohmmad. Y. Wani, Cláudia T. Arranja, Joana de A. e Silva, B. AVULA and Abilio J. F. N. Sobral, J. Mater. Chem. A, 2015,3, 19615-19637 Impact factor: 8.015
6. Wani,M. Y., Balakrishna,A., Kumar,S.,and Sobral,A.N.A review: Covalently linked free-base and metallo-bis-porphyrins: Chemistry and diversity. Current Organic Chemistry2015, 19, 599-651.Impact factor: 2.50
7. Consuelo, Y.,Arranja, C. C., Mariana,M., Balakrishna, A., Abilio, J.S., and Silva, M. R.Crystal structure of chloro-(5,10,15,20 tetra phenyl porphyrinato)-manganese,C44H28ClMnN4. Zeitschrift für Kristallographie, 2013(228)138?140.
8. Miranda,M. D., Silva,R. M.,Maria,M. R., Balakrishna,A.,and Abilio, J.S.5,10,15,20-
Tetrakis (4-acetyloxyphenyl)porphyrin including an unknown solvate.ActaCrystallographica Section E,2012 (E68) 3462–3463.
9. Balakrishna, A., Narayana, M.V., Rao, P.V., Kumar, M. A., Kumar, B. S.,Nayak, S.K., and Reddy, C. S.Synthesis and bio-activity evaluation of tetra phenyl (phenyl amino) methylene bisphosphonates as antioxidant agents and as potent inhibitors of osteoclasts in-vitro. European Journalof Medicinal Chemistry, 2011(46)1798–1802. IF: 3.5
10. Balakrishna, A., Kishore, K. C., Reddy, M.N., Rajesh, R., Nayak, S.K., Raghavan, S. C., and Reddy, C. S.Synthesis, characterization, and evaluation of cytotoxicity of novel fluoro-?- amino phosphonates in human leukemia cells.Letters in Drug Design & Discovery,2010(4) 250?259.
11. Balakrishna, A., Reddy, M.V., Nayak, S.K., Manjunath, M., Reddy, C. D., and Reddy, C.S. Synthesis, anti-bacterial, and anti-oxidant properties of thiadiazaphosphol-2-ones.Chemical and Pharmaceutical Bulletin of Japan, 2008 (56) 1486?1489.
12. Balakrishna, A., Kumar, K. S., Ramesh, K., Reddy, C. S., and Nayak, S. K. Synthesis, antibacterial, and antioxidant properties of newer 1,2- benzoxaphosphol-2-ones.Der Pharma Chemica,2009(2) 40?49.

13. Balakrishna,A., Reddy,M. V., Reddy, G. C., Krishna, B. S., Nayak, S.K., and ReddyC. S.Synthesis, anti-oxidant, and anti-bacterial properties of diethyl (4-flouro-3-nitro phenylamino) (substituted phenyl) methyl phosphonates.International Journal of Applied Biology and Pharmaceutical Technology,2010(3) 873?882.
14. Balakrishna, A., Annar, S., Reddy, M. V., Reddy, G. C.,Reddy, C. S.,and Nayak, S. K.Synthesis, anti-microbial properties of 3-(3′-chloro-4′- nitrophenyl)-2-(substituted phenoxy)-3,4-dihydro-2H-1,3,2?5–benzoxaphosphinin-2-ones.Journal of Chemical and Pharmaceutical Research, 2009(1) 250?256.
15. Balakrishna, A., Reddy, C.S., Nayak, S.K., Manjunath, M., and Raju, C.N.Synthesis, characterization, and anti-bacterial activity of some new ?-amino phosphonates. Bulletin Chemical Society of Ethiopia,2009(1) 69?75.
16. Reddy, M. V., Balakrishna, A., andReddy, C. S.Synthesis, spectral characterization, and bioassay of 3,3-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxa-phosphinines.European Journalof Medicinal Chemistry, 2010(45)1828?1832.
17. Reddy, M. V., Annar, S., BalaKrishna, A., Reddy, G. C.,and Reddy, C. S. Tetramethyl guanidine (TMG) catalyzed synthesis of novel ?-amino phosphonates by one-pot reaction.Organic Communications,2010(3) 39?44.
18. Reddy, K. K., Naidu K. R., Balakrishna, A., Krishna, P. H.,and Reddy, C. S. Synthesis, antimicrobial activity of alkyl/aryl [3-(4-substitutedphenyl)-2-thioxo-3,4-dihydro-2H-1,3,2?5-benzoxazaphosphinin-2-yl]phosphates.Journal of Korean Chemical Society,2010(5) 653?658.
19. Reddy, G. C.,Annar S., Rao,K. U., Balakrishna, A., and Reddy, C. S. Synthesis and anti-microbial activity of a new class of ?-aminophosphonic acid esters by using TMG as catalyst.Der Pharma Chemica, 2010(1) 177?184.
20. Reddy, M. V., BalaKrishna, A., Kumar, M.A., Reddy, G. C., and Reddy, C. S.One step synthesis and bioassay of N-phosphoramidophosphonates.Chemical and Pharmaceutical Bulletin of Japan, 2009(12)1391?1395.
21. Reddy, P. V., BalaKrishna, A., Reddy, M. V., Annar, S., and Reddy, C. S.Synthesis, characterization, and antimicrobial activity of novel 2-alkoxy carbonyl amino, 1,3,2 benzodiazophosphole 2–oxides.Journal of Chemical Research, 2009(3)65?67.
22. Kumar, B. S., Reddy, M. V., Reddy, G. C., BalaKrishna, A.,and Reddy, C. S. Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted aminoacid ester-12H- dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides.Bulgarian Chemical Communications,2009(4) 422?426.
23. Kumar, M.A., Balakrishna, A., Babu, B.H.,Reddy, C. B., and Reddy, C. S.Phosphomolybdic acid/SiO2 as heterogeneous solid catalyst for the rapid synthesis of N-substituted pyrroles.Synthetic Communications,2008(38) 3456?3464.
24. Kumar,B.S., Sankar,A.U., Reddy M.V., Balakrishna,A.,and Reddy C. S.One- pot synthesis and antimicrobial activity of a new class of ?-aminophosphonic acid esters.Bulgarian Chemical Communications, 2008(40) 59?64.
25. Kasthuraiah, M., Reddy, K. R., Balakrishna, A., Reddy, C. S., and Reddy,C. D. Synthesis of new class of phosphorus and oxygen macroheterocycles.Journal of Chemical Research, 2007(1) 48?54.
26. Reddy, M. V., Kumar, B. S., Balakrishna,A., Reddy,C.S., Nayak,S.K.,and Reddy,C.D. One-pot synthesis of novel ?-aminophosphonates using TMG as a catalyst. Arkivoc, 2007(15) 246?254.
Manuscripts/PatentsSubmitted and in Preparation

1. Balakrishna,A., Silvia,J.A., Veloso,H.B., Dias, C. M. F., and Sobral, A. J.Synthesis, theoretical and experimental studies of anthracene based MOFs for CO2 capture. (In preparation forRSC Advances).

Abstracts and Conference Presentations

1. Balakrishna, A., Participated as a delegate,The Indian Science Congress Association,Professional body under Department of Science and Technology, S.V. University, Tirupati, India (January 3-7, 2017).
2. Balakrishna, A.,Dias,C. M., and Sobral, A. J.Synthesis and characterization of anthracene based MOFs for CO2 capture in environmental applications,The International Conference onMaterials 2013, FCTUC, University of Coimbra, Coimbra, Portugal(Poster presentation; March 25-27,2013).
3. Dias, C. M.,Balakrishna,A., and Sobral,A. J. Pyrrolic nano-machines: synthesis and computational simulation,The International Conference on Materials 2013,FCTUC, University of Coimbra, Coimbra, Portugal(Poster presentation; March 25-27,2013).
4. BalaKrishna,A., Kishore, K. C., Reddy, M. V., Nayak, S.K., Raghavan, S. C., and Reddy, C. S. Synthesis, characterization, and evaluation of cytotoxicity of novel fluoro-?- aminophosphonates in human leukemia cells. The International Conference on Current Trends in Chemistry and Biochemistry, Bangalore University, Bangalore, India(poster presentation; December 18-19,2009).
5. Balakrishna, A.,and Reddy,C. S.Synthesis, anti-bacterial, and anti-oxidant properties of thiadiazaphosphol-2-ones.The National Conference on National Conference on Recent Advances in Chemical Research, Osmania University, Hyderabad, India (Poster presentation; Feb 6-7, 2009).
6. Balakrishna, A., Reddy, M. V., and Reddy, C. S.Synthesis, antibacterial, and antioxidant properties of newer 1,2-benzoxaphosphol-2-ones.The National Conference on National Symposium on Recent Trends in Organic and Medicinal Chemistry, National Institute of Technology, Warangal, India (Poster presentation; January 16-17,2009).
7. Balakrishna, A., Participated as a delegate,The Environmentally Benign Synthetic Methodologies in Chemistry, University College of Sciences, Kakatiya University,Warangal, India(February 9, 2009).
8. Balakrishna, A., Reddy, C.S., Nayak, S.K., Manjunath, M., and Raju, C.N.,Synthesis, characterization, and anti-bacterial activity of some new ?-amino phosphonates.The National Conference Emerging Trends in Chemical Research, Annamalai University, Chidambaram, India (Poster presentation;October 17-18, 2008).


Dr. C. Suresh Reddy Dr. C. Devendranath Reddy
Department of Chemistry Department of Chemistry
Sri Venkateswara University Sri VenkateswaraUniversity
Tirupati, 517502, India Tirupati-517502, India
E-mail: E-mail:
Tel: (91) 984-969-4958 Tel: (91)944-018-9008

Dr. Abilio J..N. Sobral
Department of Chemistry
University of Coimbra
Coimbra-3004535, Portugal
Tel: (351)938-699-998